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| l | Dose responses |
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| show the overall |
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| effect of a
mutation |
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| l | Kinetic
parameters |
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| were determined
for |
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| several key
mutants |
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| l | Glu 177 and Arg
180 |
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| mutations effect
kcat |
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| l | Tyr 80 and Asn
209 |
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| effect Km |
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